Felzenszwalb I, Pelielo de Mattos J C, Bernardo-Filho M, Caldeira-de-Araújo A
Universidade do Estado do, Rio de Janeiro, Instituto de Biologia, Departamento de Biofísica e Biometria, Brazil.
Food Chem Toxicol. 1998 Dec;36(12):1079-84. doi: 10.1016/s0278-6915(98)00082-9.
There is overwhelming evidence to indicate that free radicals cause oxidative damage to lipids, proteins and nucleic acids and are involved in the pathogenesis of several degenerative diseases. Therefore, antioxidants, which can neutralize free radicals, may be of central importance in the prevention of these disease states. The protection that fruits and vegetables provide against disease has been attributed to the various antioxidants contained in them. Recently, an anti-inflammatory and analgesic activity of a water-soluble fraction from shark cartilage has been described. Using electrophoretical assays, bacteria survival and transformation and the Salmonella/mammalian-microsome assay, we investigated the putative role of shark cartilage-containing preparation in protecting cells against reactive oxygen species induced DNA damage and mutagenesis. If antimutagens are to have any impact on human disease, it is essential that they are specifically directed against the most common mutagens in daily life. Our data suggest that shark cartilage-containing preparation can play a scavenger role for reactive oxygen species and protects cells against inactivation and mutagenesis.
有大量证据表明，自由基会对脂质、蛋白质和核酸造成氧化损伤，并参与多种退行性疾病的发病过程。因此，能够中和自由基的抗氧化剂可能在预防这些疾病状态中至关重要。水果和蔬菜对疾病的预防作用归因于其中所含的各种抗氧化剂。最近，有人描述了鲨鱼软骨水溶性部分的抗炎和镇痛活性。我们使用电泳分析、细菌存活与转化以及沙门氏菌/哺乳动物微粒体试验，研究了含鲨鱼软骨制剂在保护细胞免受活性氧诱导的DNA损伤和诱变方面的假定作用。如果抗诱变剂要对人类疾病产生任何影响，那么它们必须专门针对日常生活中最常见的诱变剂。我们的数据表明，含鲨鱼软骨制剂可以对活性氧起到清除作用，并保护细胞免受失活和诱变。
