弹簧与拉链：SNARE介导的膜融合中的卷曲螺旋

Springs and zippers: coiled coils in SNARE-mediated membrane fusion.

作者信息

Harbury P A

机构信息

Department of Biochemistry Beckman B437 Stanford University Stanford CA 94305 USA.

出版信息

Structure. 1998 Dec 15;6(12):1487-91. doi: 10.1016/s0969-2126(98)00147-6.

DOI:10.1016/s0969-2126(98)00147-6

PMID:9862813

Abstract

A conserved molecular machinery based on SNARE proteins catalyzes most, if not all, cellular membrane fusion events. A flurry of recent biophysical studies have established a detailed molecular picture of the core SNARE complex. Structural and biochemical analysis of the SNARE machinery is rapidly advancing our understanding of the specificity, regulation and protein catalysis of membrane fusion.

摘要

基于SNARE蛋白的保守分子机制催化了大多数（即便不是全部）细胞内膜融合事件。最近一系列生物物理研究已建立了核心SNARE复合体的详细分子图景。对SNARE机制的结构和生化分析正在迅速提升我们对膜融合特异性、调控及蛋白质催化的理解。