Tang X C
Department of Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.
Zhongguo Yao Li Xue Bao. 1996 Nov;17(6):481-4.
Hup A, a novel alkaloid isolated from Chineses herb Huperzia serrata, is a potent and selective inhibitor of AChE, with a rapid absorption and penetration into the brain in experimental animals. The inhibition is reversible with a longer duration of action. Hup A exhibited memory-enhancing activities in a broad range of animal cognitive model. Compared to Phy, Tac, and Gal, Hup A has better therapeutic indices, and peripheral cholinergic side effects are minimal at therapeutic doses. These findings suggest that Hup A is a promising candidate for clinical development as a symptomatic treatment for AD.
石杉碱甲是从中国草药蛇足石杉中分离出的一种新型生物碱，是一种强效且选择性的乙酰胆碱酯酶抑制剂，在实验动物中吸收迅速且能穿透血脑屏障。这种抑制作用是可逆的，作用持续时间较长。石杉碱甲在多种动物认知模型中均表现出记忆增强活性。与毒扁豆碱、他克林和加兰他敏相比，石杉碱甲具有更好的治疗指数，且治疗剂量下外周胆碱能副作用极小。这些研究结果表明，石杉碱甲作为治疗阿尔茨海默病的对症治疗药物，是临床开发的一个有前景的候选药物。
