Pang J X, Sun L S, Wang X Y, Yang S Q, Shan C W
Department of Pharmacology, First Military Medical University, Guangzhou, China.
Zhongguo Yao Li Xue Bao. 1996 Nov;17(6):500-2.
To study the effect of procainamide (PA) on pulmonary thromboembolism, platelet malondialdehyde (MDA) level and platelet aggregation induced by collagen and adrenaline.
Pulmonary thromboembolism, 2-thiobarbituric acid fluorescence micro-determination, conventional microscopic counting, and platelet aggregation test were used.
PA (10-20 mg.kg-1) and mannitol (200 mg.kg-1) reduced thrombosis by 30%-75% and 75%, respectively. Thrombocytopenia followed thrombosis increased after the pretreatment of PA and mannitol. MDA decreased by both of them in vivo. In vitro, PA inhibited platelet aggregation and MDA production induced concentration-dependently by collagen and adrenaline.
Inhibition of PA on pulmonary thromboembolism is involved in the decrease of platelet aggregation and MDA production.
