Shan C W, Lin J H, Jin Y H
Department of Pharmacology, First Military Medical University, Guangzhou, China.
Zhongguo Yao Li Xue Bao. 1998 Mar;19(2):164-6.
To study the influences of procainamide (PA) on thrombin-induced rabbit platelet aggregation and thromboxane B2 (TXB2) production in vitro.
Turbidimetry and radioimmunoassay were used.
PA 8.5, 34, 136, and 544 mumol.L-1 inhibited thrombin-induced platelet aggregation and TXB2 production, and the inhibitory rates were 45% +/- 37%, 48% +/- 32%, 88% +/- 23%, 92% +/- 15% and 53% +/- 24%, 65% +/- 26%, 90% +/- 6%, 95% +/- 6%, respectively. There was positive correlation between PA concentration and efficiency of inhibition of platelet aggregation and TXB2 production, and also between the inhibition % of platelet aggregation and that of production of TXB2. The three linear equations and main parameters were Y = 0.2075X-4.9157, r = 0.9985; Y = 0.9546X-34.6724, r = 0.9921; Y = 0.8202X + 19.7062, r = 0.9921.
PA inhibited thrombin-induced platelet aggregation and TXB2 production in rabbits.
研究普鲁卡因酰胺（PA）对凝血酶诱导的兔血小板聚集及血栓素B2（TXB2）体外生成的影响。
采用比浊法和放射免疫分析法。
8.5、34、136和544μmol·L-1的PA抑制凝血酶诱导的血小板聚集及TXB2生成，抑制率分别为45%±37%、48%±32%、88%±23%、92%±15%和53%±24%、65%±26%、90%±6%、95%±6%。PA浓度与血小板聚集及TXB2生成的抑制效率之间呈正相关，血小板聚集抑制率与TXB2生成抑制率之间也呈正相关。三个线性方程及主要参数分别为Y = 0.2075X - 4.9157，r = 0.9985；Y = 0.9546X - 34.6724，r = 0.9921；Y = 0.8202X + 19.7062，r = 0.9921。
PA抑制兔凝血酶诱导的血小板聚集及TXB2生成。
