Sun J R, Ma Y C, Xu Z H, Zhao W J, Cai Y P
College of Life Sciences, Peking University, Beijing.
Sheng Li Xue Bao. 1997 Dec;49(6):666-70.
In this work, single unit firing activities were recorded in the preoptic anterior hypothalamus (POAH) brain slices of cold acclimatized and room-temperature housed rats (CR and RR) and the effects of NE on the neuronal discharges were observed. The neurons of POAH in CR became much more sensitive to NE than that in RR (the threshold concentration of NE of CR became significantly lowered). In comparison with RR, the percentage of warm sensitive neurons that could be excited by NE was decreased and some of them even showed inhibitory responses. On the other hand, the percentage of cold sensitive neurons that could be inhibited by NE was decreased and some of them even showed excitatory responses. The percentage of thermo-insensitive neurons that could be either excited or inhibited by NE were increased.
在本研究中，记录了冷适应大鼠（CR）和室温饲养大鼠（RR）的视前区下丘脑前部（POAH）脑片的单单位放电活动，并观察了去甲肾上腺素（NE）对神经元放电的影响。与RR相比，CR的POAH神经元对NE变得更加敏感（CR的NE阈值浓度显著降低）。与RR相比，能被NE兴奋的热敏神经元百分比降低，其中一些甚至表现出抑制反应。另一方面，能被NE抑制的冷敏神经元百分比降低，其中一些甚至表现出兴奋反应。能被NE兴奋或抑制的温度不敏感神经元百分比增加。
