Fan S, Sun L, Wu Y, Zhao H, Zhang F
Department of Physiology, China Medical University, Shenyang.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Feb;13(1):71-4.
To investigate the possible central mechanism of antipyretic effects of Chinese medicines, puerarin and gypsum, the firing rate of thermosensitive neurons in preoptic-anterior hypothalamus (POAH) region of 34 cats was recorded by using extracellular micro-electrode technigue. Injection of pyrogen caused decrease in firing rate of 14 warm-sensitive neurons and increase in firing rate of 11 cold-sensitive neurons in the region of POAH. The effects could be reversed by the injection of puerarin and gypsum. The results showed the antipyretic action of puerarin and gypsum might be mediated by influences on the electroactivity of pyrogen-treated thermosensitive neurons in the region of POAH. Effect of puerarin and gypsum on cold-sensitive neurons was stronger than that of single one, suggesting that both are synergic in central level.
为探讨中药葛根和石膏解热作用的可能中枢机制，采用细胞外微电极技术记录了34只猫视前区-下丘脑前部（POAH）区域热敏神经元的放电频率。注射致热原导致POAH区域14个温敏神经元放电频率降低，11个冷敏神经元放电频率增加。注射葛根和石膏可逆转这些效应。结果表明，葛根和石膏的解热作用可能是通过影响POAH区域经致热原处理的热敏神经元的电活动来介导的。葛根和石膏对冷敏神经元的作用强于单一药物，提示二者在中枢水平上具有协同作用。
