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1-（2,6-二甲基苯氧基）-2-（3,4-二甲氧基苯乙氨基）丙烷盐酸盐对兔血小板胞浆游离钙浓度的影响

[Effects of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxy phenylethylamino) propane hydrochloride on cytosolic free calcium concentration of rabbit platelets].

作者信息

Xia J S, Luo X, Zeng F D

机构信息

Department of Clinical Pharmacology, Tongji Medical University, Wuhan.

出版信息

Yao Xue Xue Bao. 1996;31(11):872-4.

PMID:9863259
Abstract

The effects of 1-(2, 6-dimethylphenoxy)-2- (3,4-dimethoxyphenylethylamino) propane hydrochloride (DDPH) and verapamil on cytosolic free calcium concentration of rabbit platelets were investigated. The results showed that the elevation of cytosolic free calcium concentration ([Ca2+]i) of rabbit platelets following ionophore A23187 was significantly inhibited by DDPH and verapamil. The rates of inhibition with DDPH and verapamil were 58% and 78%, respectively, with no significant difference between the two groups (P > 0.05).

摘要

研究了1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙氨基)丙烷盐酸盐（DDPH）和维拉帕米对兔血小板胞浆游离钙浓度的影响。结果表明，DDPH和维拉帕米可显著抑制离子载体A23187引起的兔血小板胞浆游离钙浓度（[Ca2+]i）升高。DDPH和维拉帕米的抑制率分别为58%和78%，两组之间无显著差异（P>0.05）。

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