1-（2,6-二甲基苯氧基）-2-（3,4-二甲氧基苯乙氨基）丙烷盐酸盐（DDPH）对大鼠脑缺血损伤的保护作用
[Protective effects of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino) propane hydrochloride(DDPH) on brain ischemia injury in rats].
作者信息
Qu Ling, Wang Wei-ting, Guo Lian-jun, Wang Fang, Lü Qing, Qian Jia-qing
机构信息
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
出版信息
Yao Xue Xue Bao. 2003 Oct;38(10):725-7.
AIM
To study the effects of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino) propane hydrochloride(DDPH) on brain ischemia injury in rats.
METHODS
By using the middle cerebral artery occlusion (MCAO) induced by nylon surgical thread inserted through the internal carotid artery into the anterior cerebral artery in rats, the effects of DDPH on neuron defects(ND) and infarct size(IS) were investigated. Using incomplete cerebral ischemia in rats, the effects of DDPH on superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in brain tissue and pathological changes in rats were studied.
RESULTS
DDPH at the dose of 10 mg.kg-1 i.p. 30 min before ischemia decreased the ND 3 h after ischemia. The IS declined 24 h after ischemia as well. Meanwhile, DDPH was found to increase SOD activity and reduce the MDA content, as well as mitigate pathological damage, of neuron after brain ischemia in rats.
CONCLUSION
DDPH showed protective effects on brain ischemia, probably related to its properties of calcium antagonistic effect and increasing the activity of superoxide dismutases.
目的
研究盐酸1-（2,6-二甲基苯氧基）-2-（3,4-二甲氧基苯乙氨基）丙烷（DDPH）对大鼠脑缺血损伤的影响。
方法
采用尼龙手术线经大鼠颈内动脉插入大脑前动脉造成大脑中动脉闭塞（MCAO），研究DDPH对神经元缺损（ND）和梗死体积（IS）的影响。利用大鼠不完全性脑缺血，研究DDPH对脑组织中超氧化物歧化酶（SOD）活性、丙二醛（MDA）含量及大鼠病理变化的影响。
结果
缺血前30分钟腹腔注射10mg·kg-1剂量的DDPH可降低缺血3小时后的ND。缺血24小时后IS也下降。同时，发现DDPH可增加大鼠脑缺血后神经元的SOD活性，降低MDA含量，并减轻病理损伤。
结论
DDPH对脑缺血具有保护作用，可能与其钙拮抗作用及增加超氧化物歧化酶活性有关。
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