Tomić-Spirić V, Bogić M, Janković S, Rasković S, Djurić V, Sojić-Rajcić J
Department of Allergology and Immunology, Clinical Centre of Serbia, Belgrade.
Srp Arh Celok Lek. 1998 Jul-Aug;126(7-8):309-15.
T lymphocytes are the crucial cells in immunopathogenesis of allergic diseases since they regulate the occurrence of allergic sensitisation, synthesis of immunoglobulin E and allergic inflammation. The importance of lymphocyte T is reflected on the fact that after activation by a specific antigen they are able to produce different cytokines responsible for activation and aggregation of specific inflammatory cells in target tissues, promoting the occurrence and maintenance of allergic inflammation. Discovery of functional dichotomy of activated lymphocytes T CD4+ capable of suppressing synthesis of immunoglobulin E (Th1) or stimulate immunoglobulin E and allergic inflammation (Th2) is an important element in elucidation of pathogenesis of allergic inflammation and inadequate synthesis of immunoglobulin E. The immunoglobulin synthesis is regulated by a complex combination of factors and signals where lymphocytes CD4+ play the central regulatory role.
T淋巴细胞是过敏性疾病免疫发病机制中的关键细胞，因为它们调节过敏致敏的发生、免疫球蛋白E的合成以及过敏性炎症。淋巴细胞T的重要性体现在这样一个事实上，即它们在被特定抗原激活后能够产生不同的细胞因子，这些细胞因子负责激活和聚集靶组织中的特定炎症细胞，促进过敏性炎症的发生和维持。发现活化的CD4+ T淋巴细胞具有功能二分法，即能够抑制免疫球蛋白E的合成（Th1）或刺激免疫球蛋白E及过敏性炎症（Th2），这是阐明过敏性炎症发病机制和免疫球蛋白E合成不足的一个重要因素。免疫球蛋白的合成由多种因素和信号的复杂组合调节，其中CD4+淋巴细胞发挥着核心调节作用。
