Scalera G, Tarozzi G
Dipartimento di Scienze Biomediche, Università di Modena, Italy.
Peptides. 1998;19(9):1565-72. doi: 10.1016/s0196-9781(98)00108-9.
The effects of long-term and relatively constant concentrations of somatostatin (SRIF) were tested in rats to investigate its influence on taste preferences, fluid intake, and taste bud topography of the tongue. In SRIF-treated rats, intake of 3 x 10(-2) M NaCl and 6 x 10(-2) M sucrose solution decreased, whereas that of 3 x 10(-5) M quinine-HCl and 10(-3) M HCl (pH = 3) solutions increased significantly; distilled water intake and total fluid consumption remained almost unchanged. The light/dark cycle of consumption of NaCl solution was modified in a dose-dependent manner, but that of dwater, total fluids, and other solutions was not. Histologic exam by light microscopy showed that taste bud distribution on the tongue appeared to be altered, but the results only approached statistical significance. Given that it is possible to remove virtually all taste buds in the oral cavity and have only modest effects on preferences and aversion, it seems very unlikely that the small changes in taste bud distribution are related to the intake of sapid solutions. Since SRIF treatment influenced all sapid stimuli, it seems more likely that the changes are based on a blunted responsiveness in the gustatory system as a whole.
在大鼠中测试了长期且相对恒定浓度的生长抑素（SRIF）的作用，以研究其对味觉偏好、液体摄入量和舌部味蕾形态的影响。在接受SRIF治疗的大鼠中，3×10⁻² M NaCl和6×10⁻² M蔗糖溶液的摄入量减少，而3×10⁻⁵ M盐酸奎宁和10⁻³ M HCl（pH = 3）溶液的摄入量显著增加；蒸馏水摄入量和总液体消耗量几乎保持不变。NaCl溶液消耗的明暗周期以剂量依赖的方式改变，但蒸馏水、总液体和其他溶液的消耗周期未改变。光学显微镜组织学检查表明，舌上味蕾分布似乎发生了改变，但结果仅接近统计学意义。鉴于实际上有可能去除口腔中几乎所有的味蕾，而对偏好和厌恶的影响却很小，因此味蕾分布的微小变化似乎极不可能与有味溶液的摄入有关。由于SRIF治疗影响了所有有味刺激，因此这些变化似乎更可能是基于整个味觉系统反应迟钝。
