Bazarbachi A, El-Sabban M E, Nasr R, Quignon F, Awaraji C, Kersual J, Dianoux L, Zermati Y, Haidar J H, Hermine O, de Thé H
Departments of Internal Medicine and Biochemsitry, Human Morphology, and Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon.
Blood. 1999 Jan 1;93(1):278-83.
Human T-cell lymphotropic virus type I (HTLV-I) is the causative agent of adult T-cell leukemia/lymphoma (ATL). ATL is an aggressive proliferation of mature activated T cells associated with a poor prognosis. The combination of the antiviral agents, zidovudine (AZT) and interferon (IFN), is a potent treatment of ATL. Recently, arsenic trioxide (As) was shown to be an effective treatment of acute promyelocytic leukemia (APL). We have tested the effects of the combination of As and IFN on cell proliferation, cell cycle phases distribution, and apoptosis in ATL-derived or control T-cell lines. A high synergistic effect between IFN and As was observed in ATL-derived cell lines in comparison to the control cell lines, with a dramatic inhibition of cell proliferation, G1 arrest, and induction of apoptosis. Similar results were obtained with fresh leukemia cells derived from an ATL patient. Although the mechanisms involved are unclear, these results could provide a rational basis for combined As and IFN treatments in ATL.
人类嗜T细胞病毒I型（HTLV-I）是成人T细胞白血病/淋巴瘤（ATL）的病原体。ATL是成熟活化T细胞的侵袭性增殖，预后不良。抗病毒药物齐多夫定（AZT）和干扰素（IFN）联合使用是治疗ATL的有效方法。最近，三氧化二砷（As）被证明是治疗急性早幼粒细胞白血病（APL）的有效药物。我们测试了As和IFN联合使用对ATL来源或对照T细胞系的细胞增殖、细胞周期阶段分布和凋亡的影响。与对照细胞系相比，在ATL来源的细胞系中观察到IFN和As之间有高度协同作用，对细胞增殖有显著抑制、G1期阻滞并诱导凋亡。从一名ATL患者获得的新鲜白血病细胞也得到了类似结果。尽管其中涉及的机制尚不清楚，但这些结果可为ATL中As和IFN联合治疗提供合理依据。
