McKenzie M W, Marchall G L, Netzloff M L, Cluff L E
J Pediatr. 1976 Sep;89(3):487-90. doi: 10.1016/s0022-3476(76)80560-4.
During a three-year period of prospective epidemiologic surveillance for adverse drug reactions in a pediatric population, 72 (2.0%) of 3,556 medical admissions were the result of adverse drug reactions. Antineoplastic drugs were most frequently cited as causing a reaction leading to admission. Approximately 40% of the reactions were severe, and four reactions contributed to death.
在对儿科人群药物不良反应进行的为期三年的前瞻性流行病学监测期间,3556例入院治疗病例中有72例(2.0%)是由药物不良反应所致。抗肿瘤药物是最常被提及的导致入院治疗反应的原因。约40%的反应较为严重,有4例反应导致死亡。