Le Heuzey J Y, Copie X, Piot O, Lavergne T, Henry P, Guize L
Service de cardiologie A, Hôpital Broussais, Paris.
Arch Mal Coeur Vaiss. 1998 Nov;91(11):1371-6.
Cardiac failure is a common cause of arrhythmia. Many factors predispose to the genesis of arrhythmias in these patients. A number of non-invasive methods allow stratification of the risk of arrhythmia in cardiac failure. Approximately half the deaths of these patients are due to arrhythmia. Unfortunately, most of the investigations for risk evaluation have a high negative predictive value but a lower positive predictive value. The treatment of supraventricular arrhythmias, mainly atrial fibrillation, is complex in cardiac failure. Class I antiarrhythmics are contraindicated. The only remaining options are Class II, especially Sotalol, and Class III drugs, especially Amiodarone. In some cases, non-pharmacological methods such as ablation, pacing or an implantable atrial defibrillator must be considered. The treatment of ventricular arrhythmias is also difficult. In this indication, Class I antiarrhythmic agents must also be avoided. Non-sustained ventricular tachycardia may be treated by betablockers or amiodarone. The use of an implantable defibrillator is increasingly recommended after the results of several controlled large scale trials. The indication is obvious in patients resuscitated from sudden death and these devices are also beneficial in sustained ventricular tachycardia in patients with cardiac failure. Many studies are currently under way to determine the value of this therapeutic modality in indications now considered to be "prophylactic".
心力衰竭是心律失常的常见原因。许多因素易导致这些患者发生心律失常。多种非侵入性方法可对心力衰竭患者心律失常的风险进行分层。这些患者约有一半的死亡是由心律失常所致。不幸的是,大多数用于风险评估的检查具有较高的阴性预测价值,但阳性预测价值较低。心力衰竭患者室上性心律失常(主要是房颤)的治疗较为复杂。Ⅰ类抗心律失常药物为禁忌。剩下的选择只有Ⅱ类药物,尤其是索他洛尔,以及Ⅲ类药物,尤其是胺碘酮。在某些情况下,必须考虑采用消融、起搏或植入式心房除颤器等非药物方法。室性心律失常的治疗也很困难。在此适应证中,也必须避免使用Ⅰ类抗心律失常药物。非持续性室性心动过速可用β受体阻滞剂或胺碘酮治疗。经过多项大规模对照试验后,越来越推荐使用植入式除颤器。对于从心搏骤停中复苏的患者,适应证很明确,而且这些装置对心力衰竭患者的持续性室性心动过速也有益。目前正在进行许多研究,以确定这种治疗方式在目前被视为“预防性”适应证中的价值。