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[紫杉烷类药物在乳腺癌和卵巢癌治疗中的应用:当前适应证及疗效]

[Taxanes in the treatment of breast and ovarian cancers: current indications and results].

作者信息

Espié M, Cuvier C, Gorins A, Marty M

机构信息

Centre des Maladies du Sein, Oncologie Médicale, Hôpital Saint-Louis, Paris.

出版信息

Contracept Fertil Sex. 1998 Nov;26(11):805-11.

PMID:9864888
Abstract

Since the last years, taxanes are among the most active molecules in the treatment of advanced breast and ovarian cancers. Concerning the ovarian cancer, Paclitaxel in association with Cisplatinum is about to become the first line reference protocol. Studies are going on in order to define the association and the optimal way of administration. Concerning breast cancer, Docetaxel seems to provide the most interesting response rates after failures of anthracyclines. In France, randomised studies in adjuvant situation have started with this molecule.

摘要

近年来,紫杉烷类药物是晚期乳腺癌和卵巢癌治疗中最有效的分子之一。对于卵巢癌,紫杉醇联合顺铂即将成为一线参考治疗方案。相关研究正在进行,以确定联合用药方式及最佳给药途径。对于乳腺癌,多西他赛在蒽环类药物治疗失败后似乎能提供最可观的缓解率。在法国,已开始针对该药物进行辅助治疗的随机研究。

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