Ottaviani E, Martinelli G, Testoni N, Visani G, Tani M, Tura S
Haematologica. 1998 Nov;83(11):1051-5.
Autologous bone marrow transplantation (ABMT), which consents a low mortality rate, has been proposed as an alternative approach to maintenance chemotherapy in patients with acute promyelocytic leukemia (APL) in first complete remission irrespective of the patients' molecular status. Sixteen patients with acute APL in complete remission were submitted to ABMT and were analyzed for the presence of the PML-RARa fusion gene by reverse transcription-polymerase chain reaction (RT-PCR). Our study demonstrated that continued positivity of PCR analysis before ABMT could predict subsequent relapse in patients who undergo un-purged ABMT procedures.
自体骨髓移植（ABMT）死亡率较低，已被提议作为初治完全缓解的急性早幼粒细胞白血病（APL）患者维持化疗的替代方法，无论患者的分子状态如何。16例完全缓解的急性APL患者接受了ABMT，并通过逆转录聚合酶链反应（RT-PCR）分析PML-RARa融合基因的存在情况。我们的研究表明，在接受未净化ABMT程序的患者中，ABMT前PCR分析持续呈阳性可预测随后的复发。
