Okahisa T, Sogabe M, Hayashi S, Shibata H, Ito S
Second Department of Internal Medicine, University of Tokushima School of Medicine, Japan.
J Med Invest. 1998 Aug;45(1-4):87-93.
The contrast medium-removing effect of hemofiltration (HF) and hemodiafiltration (HDF) was experimentally investigated using a bovine blood tank model. HF and HDF were performed at a blood flow rate of 100 ml/min with a polysulfone hemofilter (PS filter-CF; membrane area: 0.7 m2). Two hundred milliliters of iomeprol (300 mgI/ml) was administered by a single injection into 4 liters of bovine blood. The blood half-lives of iomeprol were 1.0 hr for the high flow rate HDF group [replacement fluid flow rate (QF): 10 ml/min and dialysate flow rate (QD): 40 ml/min], 1.8 hr for the HDF group (QF: 10 ml/min and QD: 10 ml/min), and 3.8 hr for the HF group (QF: 10 ml/min). The mean clearance rates were 39.7 ml/min for the high flow rate HDF group, 21.4 ml/min for the HDF group, and 12.0 ml/min for the HF group. Iomeprol was mostly excreted in the waste fluid. It is concluded that HDF can remove contrast media more effectively than HF.
使用牛血槽模型对血液滤过（HF）和血液透析滤过（HDF）的造影剂清除效果进行了实验研究。使用聚砜血液滤过器（PS滤器 - CF；膜面积：0.7平方米）以100毫升/分钟的血流速度进行HF和HDF。将200毫升碘海醇（300毫克碘/毫升）单次注入4升牛血中。碘海醇的血液半衰期在高流量HDF组[置换液流速（QF）：10毫升/分钟，透析液流速（QD）：40毫升/分钟]为1.0小时，在HDF组（QF：10毫升/分钟，QD：10毫升/分钟）为1.8小时，在HF组（QF：10毫升/分钟）为3.8小时。高流量HDF组的平均清除率为39.7毫升/分钟，HDF组为21.4毫升/分钟，HF组为12.0毫升/分钟。碘海醇大多排泄在废液中。得出的结论是，HDF比HF能更有效地清除造影剂。
