Bazhanov N N, Khitrov A N, Nasonov E L, Makolkin V I
Klin Med (Mosk). 1998;76(10):32-5.
To assess condition of the heart in polymyositis (PM) and dermatomyositis (DM) in terms of defects in the rhythm and conductivity, we carried out ECG, 24-hour ECG monitoring, EIA measurements of KPK MB-fraction and myoglobin, echocardiography and Doppler echocardiography. Maximal frequency of arrhythmia presenting as supraventricular and ventricular extrasystole occurred in patients with acute PM/DM. Blockade of the bundle of His left anterior branch was detected most frequently in patients with acute and subacute PM-DM and in those with high serum levels of KPK MB-faction and myoglobin. Frequency of rhythmic and conductivity disorders seems unrelated to the disease duration. We registered no alterations at rest either in intracardiac hemodynamics or myocardial contractility. The study of these parameters under exercise test may provide objective information on early defects in myocardial contractility.
为了从节律和传导缺陷方面评估多发性肌炎(PM)和皮肌炎(DM)患者的心脏状况,我们进行了心电图、24小时心电图监测、肌酸磷酸激酶MB同工酶(KPK MB)和肌红蛋白的酶免疫分析测量、超声心动图和多普勒超声心动图检查。急性PM/DM患者出现室上性和室性早搏形式的心律失常的最大频率最高。在急性和亚急性PM-DM患者以及血清KPK MB同工酶和肌红蛋白水平较高的患者中,最常检测到左前分支希氏束阻滞。节律和传导障碍的频率似乎与疾病持续时间无关。我们未发现静息时心内血流动力学或心肌收缩力有任何改变。运动试验中对这些参数的研究可能会提供有关心肌收缩力早期缺陷的客观信息。