Hansen B W, DeSomery C H, Hagedorn P K, Kalnasy L W
JPEN J Parenter Enteral Nutr. 1977;1(2):83-8. doi: 10.1177/014860717700100201.
Varied clinical observations of the presence of either hunger or anorexia during intragastric or intravenous alimentation have led to the current experiments. Nine rhesus monkeys (Macaca mulatta) were involved in studies of the long-term effects of enteral and parenteral nutrition on appetite as assessed by feeding behavior and gastric motility. The monkeys received either intragastric infusions of glucose or a complete liquid diet, or intravenous infusions of glucose or glucose/amino acid solutions. Oral intake was accurately adjusted to account for the calories administered by the intragastric route. Oral intake was also reduced in a calorically equivalent amount to account for the calories received during intravenous glucose. When glucose/amino acid solutions were administered parenterally, adjustments were less accurate, with resultant overeating and weight gain in some monkeys during parenteral nutrition, followed by prolonged suppression of appetite after cessation of the infusions. Further studies of the effects of varied compositions of parenteral nutrition, and varied methods of weaning from infusions, are indicated.
在进行胃内或静脉营养期间出现饥饿或厌食的各种临床观察结果引发了当前的这些实验。九只恒河猴（猕猴）参与了关于肠内和肠外营养对食欲的长期影响的研究，该影响通过进食行为和胃动力进行评估。这些猴子接受了胃内输注葡萄糖或完整液体饮食，或者静脉输注葡萄糖或葡萄糖/氨基酸溶液。经口摄入量会根据胃内途径给予的热量进行精确调整。经口摄入量也会以热量相当的量减少，以抵消静脉输注葡萄糖期间所摄入的热量。当通过肠外途径给予葡萄糖/氨基酸溶液时，调整就没那么精确了，结果在一些猴子的肠外营养期间出现了暴饮暴食和体重增加的情况，在输注停止后随之而来的是食欲的长期抑制。表明需要进一步研究不同成分的肠外营养的影响以及不同的从输注中断奶的方法。
