Burkhart K K, Donovan J W
Central Pennsylvania Poison Center, Penn State Geisinger Health System, Hershey 17033-0850, USA.
J Toxicol Clin Toxicol. 1998;36(7):723-5. doi: 10.3109/15563659809162622.
This case report describes a 19-year-old male who ingested a product containing butoxyethanol, propylene glycol, and monoethanolamine. Neurotoxicity, acidosis, and butoxyacetic acid persisted after hemodialysis. Hemodialysis was used to treat the acidosis, but the half-life of butoxyacetic acid did not appear to have been significantly altered. Fomepizole, a recently approved alcohol dehydrogenase inhibitor for ethylene glycol intoxication, was not available at the time of this case. Residual neurological deficits persisted after recovery from this severe intoxication by a glycol ether.
本病例报告描述了一名19岁男性,他摄入了一种含有丁氧基乙醇、丙二醇和单乙醇胺的产品。血液透析后仍存在神经毒性、酸中毒和丁氧基乙酸。血液透析用于治疗酸中毒,但丁氧基乙酸的半衰期似乎没有明显改变。在本病例发生时,最近批准用于治疗乙二醇中毒的乙醇脱氢酶抑制剂甲吡唑尚无供应。从这种严重的二醇醚中毒恢复后,残留的神经功能缺损仍然存在。