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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Industrial Toxicology Research Centre, Lucknow, India.

Hum Exp Toxicol. 1998 Nov;17(11):638-42. doi: 10.1177/096032719801701109.

Hexachlorocyclohexane (HCH), an organochlorine pesticide having hydrophobic molecule is known to act on membranes. HCH mediated alterations in erythrocyte membrane occur through disorganization of the lipid bilayer. Therefore the changes in erythrocyte membrane fluidity, osmotic fragility and certain membrane bound enzymes were studied. Administration of HCH (technical) to rats at 5 mg/kg, orally, 5 days a week for 1, 2 and 3 months caused marked increase in erythrocyte membrane fluidity, osmotic fragility and decrease in levels of Na+, K(+)-ATPase, acetylcholinesterase in erythrocytes and glutathione in blood. 2. These changes indicate that HCH adversely affects membrane structure and function.

六氯环己烷（HCH）是一种具有疏水分子的有机氯农药，已知其作用于细胞膜。HCH介导的红细胞膜改变是通过脂质双层的紊乱发生的。因此，研究了红细胞膜流动性、渗透脆性和某些膜结合酶的变化。以5毫克/千克的剂量每周口服5天，给大鼠施用HCH（工业品）1、2和3个月，导致红细胞膜流动性、渗透脆性显著增加，红细胞中Na+、K(+)-ATP酶、乙酰胆碱酯酶水平以及血液中谷胱甘肽水平降低。2. 这些变化表明HCH对膜结构和功能产生了不利影响。

Industrial Toxicology Research Centre, Lucknow, India.

Hum Exp Toxicol. 1998 Nov;17(11):638-42. doi: 10.1177/096032719801701109.

Hexachlorocyclohexane (HCH), an organochlorine pesticide having hydrophobic molecule is known to act on membranes. HCH mediated alterations in erythrocyte membrane occur through disorganization of the lipid bilayer. Therefore the changes in erythrocyte membrane fluidity, osmotic fragility and certain membrane bound enzymes were studied. Administration of HCH (technical) to rats at 5 mg/kg, orally, 5 days a week for 1, 2 and 3 months caused marked increase in erythrocyte membrane fluidity, osmotic fragility and decrease in levels of Na+, K(+)-ATPase, acetylcholinesterase in erythrocytes and glutathione in blood. 2. These changes indicate that HCH adversely affects membrane structure and function.

六氯环己烷（HCH）是一种具有疏水分子的有机氯农药，已知其作用于细胞膜。HCH介导的红细胞膜改变是通过脂质双层的紊乱发生的。因此，研究了红细胞膜流动性、渗透脆性和某些膜结合酶的变化。以5毫克/千克的剂量每周口服5天，给大鼠施用HCH（工业品）1、2和3个月，导致红细胞膜流动性、渗透脆性显著增加，红细胞中Na+、K(+)-ATP酶、乙酰胆碱酯酶水平以及血液中谷胱甘肽水平降低。2. 这些变化表明HCH对膜结构和功能产生了不利影响。