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Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid.

作者信息

Mechoulam R, Fride E, Ben-Shabat S, Meiri U, Horowitz M

机构信息

Hebrew University, School of Pharmacy, Medical Faculty, Jerusalem, Israel.

出版信息

Eur J Pharmacol. 1998 Nov 27;362(1):R1-3. doi: 10.1016/s0014-2999(98)00777-8.

DOI:10.1016/s0014-2999(98)00777-8
PMID:9865537
Abstract

The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor.

摘要

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