Rucci L, Gammarota L, Simonetti L, Cirri M B
Otorhinolaryngology Clinic, University of Florence, Italy.
Ann Otol Rhinol Laryngol. 1998 Dec;107(12):1038-45. doi: 10.1177/000348949810701208.
The TNM classification is unsatisfactory regarding the impaired mobility of the vocal cord and/or the arytenoid. The authors have studied the intrinsic laryngeal musculature, with particular attention to the medial thyroarytenoid muscle, the lateral thyroarytenoid muscle, and the inferior paraglottic space. The study was conducted on serial sections of 4 embryonal and 9 fetal larynges at different stages of development. The embryological observations showed that the lateral and medial thyroarytenoid muscles have different maturation times and probably different functions: phonatory and sphincteric. The authors have found that the inferior paraglottic space is situated between these 2 muscles. It would represent a path of diffusion for glottic cancer and play a central role in impaired vocal cord and/or arytenoid mobility, according to the degree of diffusion. Embryological observations have suggested the existence of laryngeal morphofunctional units belonging to the subsites of the glottic region and related to tumoral spreading.
就声带和/或杓状软骨活动受限而言，TNM分类并不令人满意。作者研究了喉内肌，特别关注了甲杓内侧肌、甲杓外侧肌和下咽旁间隙。该研究是在4个胚胎期和9个不同发育阶段胎儿的喉部连续切片上进行的。胚胎学观察表明，甲杓外侧肌和甲杓内侧肌有不同的成熟时间，可能有不同的功能：发声功能和括约肌功能。作者发现下咽旁间隙位于这两块肌肉之间。根据扩散程度，它可能是声门癌的扩散途径，并在声带和/或杓状软骨活动受限中起核心作用。胚胎学观察提示存在属于声门区亚部位且与肿瘤扩散相关的喉形态功能单位。
