Nishizuka M
Neuroendocrinology. 1976;20(2):157-65. doi: 10.1159/000122479.
82% of female mice, that had received a single injection of 50 mug testosterone propionate (TP) at 4 days of age, became persistent estrous by 90 days. If 50 mug pentobarbital or 10 mug reserpine was given simultaneously with TP, the incidence of hypothalamic masculinization (persistent estrus (PE) and polyfollicular ovaries lacking corpora lutea) at 90 days dropped to 33 and 30%, respectively. Phenoxybenzamine (50 mug) also decreased the incidence of PE to 20 and 30% at 60 and 90 days of age, respectively. However, propranolol failed to nullify the masculinization caused by TP. These results seem to suggest that a monoaminergic mechanism is involved in the hypothalamic masculinization of neonatal mice.
82%在4日龄时单次注射50微克丙酸睾酮（TP）的雌性小鼠，到90日龄时出现持续发情。如果在注射TP的同时给予50微克戊巴比妥或10微克利血平，90日龄时下丘脑雄性化（持续发情（PE）和缺乏黄体的多囊卵巢）的发生率分别降至33%和30%。酚苄明（50微克）在60日龄和90日龄时也分别将PE的发生率降至20%和30%。然而，普萘洛尔未能消除TP引起的雄性化。这些结果似乎表明单胺能机制参与了新生小鼠的下丘脑雄性化过程。
