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纤维荧光原位杂交揭示出在无精子症男性中经常缺失的Y染色体区域内明显聚集着7个DAZ基因或假基因。

Fibre-fluorescence in situ hybridization unravels apparently seven DAZ genes or pseudogenes clustered within a Y-chromosome region frequently deleted in azoospermic males.

作者信息

Gläser B, Yen P H, Schempp W

机构信息

Institute of Human Genetics and Anthropology, University of Freiburg, Germany.

出版信息

Chromosome Res. 1998 Sep;6(6):481-6. doi: 10.1023/a:1009256613348.

Abstract

Using the technique of 'fibre-FISH' (fluorescence in situ hybridization), we describe the direct visualization of seven longer DAZ signal stretches and in addition a maximum of four isolated single DAZ signals on Y-chromatin fibres of four different individuals. These seven longer DAZ signal stretches may represent seven DAZ genes or pseudogenes, whereas the single DAZ signals may represent truncated DAZ genes.

摘要

运用“纤维荧光原位杂交(Fibre-FISH)”技术,我们描述了在四个不同个体的Y染色体纤维上直接观察到七个较长的DAZ信号片段,此外还最多观察到四个孤立的单个DAZ信号。这七个较长的DAZ信号片段可能代表七个DAZ基因或假基因,而单个DAZ信号可能代表截短的DAZ基因。

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