Mendell J R, Silverman L M, Verrill H L, Parker J M, Olson W H
Neurology. 1976 Oct;26(10):968-74. doi: 10.1212/wnl.26.10.968.
Imipramine and serotonin (5-HT) were used to produce a myopathy in rats. Imipramine was used to stimulate a defect in transport of 5-HT observed in the platelets of Duchenne's dystrophy patients. The most effective dosage schedule was imipramine, 10 mg per kilogram, for 7 days followed by 5-HT, 100 mg per kilogram, 6 hours after the final imipramine dose. A single series of injections produced focal groups of necrotic and regenerating muscle fibers. In some rats, multiple series of injections resulted in a chronic myopathy with a predilection for proximal muscles, particularly quadriceps. In addition to skeletal muscle lesions, focal areas of myocardial damage were seen. The affected rats had a marked elevation of plasma creatine phosphokinase (including MB isoenzyme), serum glutamic oxaloacetic transaminase, and lactic dehydrogenase. Femoral nerve section did not affect the development of muscle lesions.
丙咪嗪和血清素（5-羟色胺）被用于在大鼠中诱发一种肌病。丙咪嗪被用于引发在杜兴氏肌营养不良症患者血小板中观察到的5-羟色胺转运缺陷。最有效的给药方案是丙咪嗪，每千克10毫克，持续7天，然后在最后一剂丙咪嗪给药6小时后给予5-羟色胺，每千克100毫克。单次注射会产生局部坏死和再生肌纤维群。在一些大鼠中，多次注射会导致一种慢性肌病，该肌病易累及近端肌肉，尤其是股四头肌。除了骨骼肌损伤外，还可见心肌损伤的局部区域。受影响的大鼠血浆肌酸磷酸激酶（包括MB同工酶）、血清谷氨酸草酰乙酸转氨酶和乳酸脱氢酶显著升高。股神经切断术并不影响肌肉损伤的发展。
