[The toxic component in the development of lung damages in uremia].

Renal ischemia causes accumulation of middle-sized molecular components of peptide and non-peptide character in the blood. These substances, obtained from the blood by method of ultrafiltration are able to cause the marked lung injuries with formation of leukocyte and erythrocyte aggregations, endothelial lung cell injured and with the phenomenon of hyperhydration. The indicated changes are proportional by their expressiveness to the dose of administrated middle-sized molecules. The conclusion can be made that toxic component, associated with accumulation of biologically active middle-sized molecules in the blood plays a significant role in the development of nephrogenic pulmonary edema.