一项配对研究，以确定低剂量阿司匹林联合肝素是否能提高冻融胚胎移植后的妊娠率和/或影响子宫内膜超声参数。
A matched study to determine whether low-dose aspirin without heparin improves pregnancy rates following frozen embryo transfer and/or affects endometrial sonographic parameters.
作者信息
Check J H, Dietterich C, Lurie D, Nazari A, Chuong J
机构信息
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Camden, New Jersey, USA.
出版信息
J Assist Reprod Genet. 1998 Nov;15(10):579-82. doi: 10.1023/a:1020373009043.
Abstract
PURPOSE
The objective of the matched, controlled study was to determine whether low-dose aspirin therapy without heparin improves pregnancy rates following frozen embryo transfer.
METHODS
Thirty-six women who did not achieve a pregnancy following fresh embryo transfer and who had frozen embryos available for another transfer were included. Eighteen women were treated with 81 mg aspirin from day 2 of the cycle through pregnancy testing. If the beta-human chorionic gonadotropin level was positive, aspirin was continued through the pregnancy. Eighteen women were not given aspirin. The mean outcome variables were pregnancy and implantation rates.
RESULTS
The clinical pregnancy rate in the aspirin group was 11.1%, compared with 33.3% for the controls, and implantation rates were 2.9 and 10.9%, respectively.
CONCLUSIONS
No positive effects of low-dose aspirin therapy on pregnancy rates following frozen embryo transfer were observed.
摘要
目的
该项配对对照研究的目的是确定在不使用肝素的情况下，低剂量阿司匹林治疗能否提高冷冻胚胎移植后的妊娠率。
方法
纳入36名在新鲜胚胎移植后未妊娠且有可用于再次移植的冷冻胚胎的女性。18名女性从 cycle 的第2天开始至妊娠检测期间接受81毫克阿司匹林治疗。如果β-人绒毛膜促性腺激素水平呈阳性，则在整个孕期继续使用阿司匹林。18名女性未服用阿司匹林。平均结局变量为妊娠率和着床率。
结果
阿司匹林组的临床妊娠率为11.1%，对照组为33.3%，着床率分别为2.9%和10.9%。
结论
未观察到低剂量阿司匹林治疗对冷冻胚胎移植后的妊娠率有积极影响。
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本文引用的文献
1
Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study.低剂量阿司匹林用于子宫内膜薄的卵母细胞捐赠受者：前瞻性随机研究。
Fertil Steril. 1997 Nov;68(5):927-30. doi: 10.1016/s0015-0282(97)00330-0.
2
The effect of assisted hatching on pregnancy rates after frozen embryo transfer.
Fertil Steril. 1996 Feb;65(2):254-7. doi: 10.1016/s0015-0282(16)58080-7.
3
The effect of endometrial thickness and echo pattern on in vitro fertilization outcome in donor oocyte-embryo transfer cycle.
Fertil Steril. 1993 Jan;59(1):72-5. doi: 10.1016/s0015-0282(16)55617-9.
4
The benefits of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception.低剂量阿司匹林疗法对辅助受孕期间子宫灌注受损女性的益处。
Hum Reprod. 1994 Oct;9(10):1954-7. doi: 10.1093/oxfordjournals.humrep.a138366.
5
High fecundity rates following in-vitro fertilization and embryo transfer in antiphospholipid antibody seropositive women treated with heparin and aspirin.接受肝素和阿司匹林治疗的抗磷脂抗体血清阳性女性在体外受精和胚胎移植后的高受孕率。
Hum Reprod. 1994 Dec;9(12):2278-83. doi: 10.1093/oxfordjournals.humrep.a138437.
6
Influence of endometrial thickness and echo patterns on pregnancy rates during in vitro fertilization.
Fertil Steril. 1991 Dec;56(6):1173-5. doi: 10.1016/s0015-0282(16)54736-0.
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