现代超声子宫内膜参数对胚胎移植成功率的影响及治疗选择——第1部分：增殖晚期子宫内膜厚度的重要性
The importance of sonographic endometrial parameters in influencing success following embryo transfer in the modern era and therapeutic options--part 1: the importance of late proliferative phase endometrial thickness.
作者信息
Check J H
出版信息
Clin Exp Obstet Gynecol. 2011;38(3):197-200.
PURPOSE
To evaluate the importance in the modern era of either too thin or too thick of an endometrium in the late proliferative phase on success following embryo transfer.
METHODS
Pregnancy rates following fresh embryo transfer in cycles using controlled ovarian hyperstimulation and following donor egg or frozen embryo transfers using artificial estrogen-replaced cycles according to endometrial thickness were determined.
RESULTS
A thin endometrium has a negative impact on success following embryo transfer but improvement in IVF technology makes this confounding variable much less important than in the early days of IVF. Too thick of an endometrium does not seem to negatively impact success.
CONCLUSIONS
Treatment options, e.g., low-dose aspirin, sildenafil or vaginal estradiol are of marginal value in improving endometrial thickness or outcome. For those with a good frozen embryo program the best option may be to cryopreserve all embryos and transfer in a subsequent graduated estrogen/progesterone replacement cycle.
目的
评估在现代，增殖晚期子宫内膜过薄或过厚对胚胎移植成功率的影响。
方法
根据子宫内膜厚度，测定在使用控制性卵巢过度刺激的周期中进行新鲜胚胎移植后的妊娠率，以及在使用人工雌激素替代周期进行供体卵或冷冻胚胎移植后的妊娠率。
结果
薄型子宫内膜对胚胎移植成功率有负面影响，但体外受精技术的进步使这个混杂变量的重要性比体外受精早期大大降低。子宫内膜过厚似乎不会对成功率产生负面影响。
结论
治疗方案，如低剂量阿司匹林、西地那非或阴道雌二醇，在改善子宫内膜厚度或结局方面价值有限。对于拥有良好冷冻胚胎程序的患者，最佳选择可能是冷冻所有胚胎，并在随后的递增雌激素/孕激素替代周期中进行移植。
Zotero 插件