Pieniazek D, Baggs J, Hu D J, Matar G M, Abdelnoor A M, Mokhbat J E, Uwaydah M, Bizri A R, Ramos A, Janini L M, Tanuri A, Fridlund C, Schable C, Heyndrickx L, Rayfield M A, Heneine W
HIV/Retrovirus Diseases Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Emerg Infect Dis. 1998 Oct-Dec;4(4):649-56. doi: 10.3201/eid0404.980418.
HIV genetic variability, phylogenetic relationships, and transmission dynamics were analyzed in 26 HIV-infected patients from Lebanon. Twenty-five specimens were identified as HIV-1 and one as HIV-2 subtype B. The 25 strains were classified into six env-C2-V3 HIV-1 subtypes: B (n = 10), A (n = 11), C (n = 1), D (n = 1), G (n = 1), and unclassifiable. Potential recombinants combining parts of viral regions from different subtypes Aenv/Dpol/Agag, Genv/Apol, and the unclassifiable-subtype(env)/unclassifiable-subtype(pol)/Agag were found in three patients. Epidemiologic analysis of travel histories and behavioral risks indicated that HIV-1 and HIV-2 subtypes reflected HIV strains prevalent in countries visited by patients or their sex partners. Spread of complex HIV-subtype distribution patterns to regions where HIV is not endemic may be more common than previously thought. Blood screening for both HIV-1 and HIV-2 in Lebanon is recommended to protect the blood supply. HIV subtype data provide information for vaccine development.
对来自黎巴嫩的26名HIV感染患者的HIV基因变异性、系统发育关系及传播动态进行了分析。25份标本被鉴定为HIV-1，1份为HIV-2 B亚型。这25株病毒被分为6种env-C2-V3 HIV-1亚型：B型（n = 10）、A型（n = 11）、C型（n = 1）、D型（n = 1）、G型（n = 1）以及无法分类的类型。在3名患者中发现了潜在重组体，它们分别组合了来自不同亚型的病毒区域部分，即Aenv/Dpol/Agag、Genv/Apol以及无法分类亚型的env/无法分类亚型的pol/Agag。对旅行史和行为风险的流行病学分析表明，HIV-1和HIV-2亚型反映了患者或其性伴侣所访问国家中流行的HIV毒株。复杂的HIV亚型分布模式向HIV非流行地区的传播可能比之前认为的更为常见。建议在黎巴嫩对HIV-1和HIV-2进行血液筛查以保护血液供应。HIV亚型数据为疫苗研发提供了信息。
