Cercueil J P, Jacob D, Verges B, Holtzmann P, Lerais J M, Krause D
Department of Imaging, CHU Le Bocage, Dijon, France.
Eur Radiol. 1998;8(9):1565-9. doi: 10.1007/s003300050587.
The aim of this study was to evaluate mid- and long-term results of ultrasonically guided ethanol injection into parathyroid adenomas. From 1988 to 1996, 27 patients (mean age 77 +/- 13 years) were treated for parathyroid adenomas by percutaneous ethanol injection. The survey included clinical information, plasma calcium, phosphorus and PTH (1-84) evaluation. Follow-up lasted 22.6 +/- 10 months. No major complications were observed for 63 ethanol injections. Biochemical recovery was 58%, biochemical improvement at 3 months was 33%, and failure was 7%. Four of 15 cured patients presented a recurrence of the disease 1 or 2 years after the first treatment. Ultrasonically guided ethanol injection can be useful in the treatment of parathyroid adenomas when surgery is not possible. The immediate results are interesting but not as good as those obtained with surgery. A regular biochemical survey is necessary so that recurrences can be recognized and treated at an early stage.
本研究的目的是评估超声引导下乙醇注射治疗甲状旁腺腺瘤的中长期效果。1988年至1996年，27例（平均年龄77±13岁）甲状旁腺腺瘤患者接受了经皮乙醇注射治疗。调查内容包括临床信息、血浆钙、磷及甲状旁腺激素（1-84）评估。随访时间为22.6±10个月。63次乙醇注射未观察到严重并发症。生化指标恢复率为58%，3个月时生化指标改善率为33%，失败率为7%。15例治愈患者中有4例在首次治疗后1或2年疾病复发。当无法进行手术时，超声引导下乙醇注射可用于治疗甲状旁腺腺瘤。即时效果令人满意，但不如手术治疗效果好。需要定期进行生化检查，以便早期发现并治疗复发情况。
