Tulassay Z
Second Dept. of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Scand J Gastroenterol Suppl. 1998;228:115-21. doi: 10.1080/003655298750026642.
Somatostatin has various significant effects on the gastrointestinal tract: it inhibits the release of several gastrointestinal hormones, blocks the exocrine function of the stomach and the pancreas, and decreases the motility of both the stomach and the gut. Its physiological effects make it potentially useful in the therapy of various gastrointestinal diseases and disorders. Somatostatin is effective in the management of active variceal bleeding and increases the effectiveness of sclerotherapy. Previous studies show controversial data about the efficacy of somatostatin in preventing complications following endoscopic retrograde cholangiopancreatography. The use of this compound may be indicated only in high-risk patients in whom endoscopic sphincterotomy may also become necessary. The perioperative use of somatostatin decreases the risk of pancreatic surgery and its application is effective in promoting the closure of pancreatic fistulae. The somatostatin analogue octreotide has a definitive role in the medical management of hormone-secreting neuroendocrine tumours of the gut.
它抑制多种胃肠激素的释放，阻断胃和胰腺的外分泌功能，并降低胃和肠道的蠕动。其生理作用使其在治疗各种胃肠道疾病和紊乱方面具有潜在用途。生长抑素在治疗活动性静脉曲张出血方面有效，并可提高硬化疗法的疗效。先前的研究关于生长抑素在预防内镜逆行胰胆管造影术后并发症的疗效存在争议性数据。仅在可能也需要进行内镜括约肌切开术的高危患者中才可能使用这种化合物。生长抑素的围手术期使用可降低胰腺手术的风险，其应用在促进胰瘘闭合方面有效。生长抑素类似物奥曲肽在肠道分泌激素的神经内分泌肿瘤的药物治疗中具有明确作用。
