Peterson C M, Ahkavan M, Fernandez-Soto M L, Rowell C, Scott B K, Peterson K P
Sansum Medical Research Foundation, Santa Barbara, CA 93105, USA.
Autoimmunity. 1998;28(3):157-61. doi: 10.3109/08916939808996284.
Dapsone (4,4'-diaminodiphenyl sulfone) is a compound that has a large clinical experience due to its antimicrobial effects against mycobacterium leprae, the causative agent of leprosy. It is increasingly used in a number of clinical situations where inflammation may play an ancillary role. An inhibitory effect of the drug or lack thereof in the cumulative incidence or propagation of diabetes mellitus in the NOD mouse has mechanistic as well as therapeutic implications. We previously showed that dapsone administered continuously as a percentage of food to NOD mice inhibits the cumulative incidence of diabetes in a dose dependent fashion. In the present experiment, female NOD litter mates were randomized to receive dapsone (0.001% w/w as a percentage of food) at onset of diabetes. There were no differences in weight, blood glucose, or glycated hemoglobin at 10 weeks of age among the animals that were ultimately to receive dapsone (n = 10), mouse chow alone (n = 9), or those who did not develop diabetes (n = 3). The mean time to onset of diabetes, mean blood glucose at onset, and mean glycated hemoglobin at onset did not differ between animals who did or did not receive dapsone. Animals receiving dapsone had significantly (p < or = 0.03) lower glycated hemoglobin at weeks 2, 3, and 4 following the onset of diabetes and lived significantly longer following diagnosis of diabetes (7 vs. 4 weeks, p < 0.05). In conclusion, dapsone modulates the progression of autoimmune diabetes in the NOD mouse even when administered after the initiation of hyperglycemia.
氨苯砜（4,4'-二氨基二苯砜）是一种因对麻风病病原体麻风杆菌具有抗菌作用而拥有大量临床经验的化合物。它在炎症可能起辅助作用的多种临床情况中使用得越来越多。该药物对非肥胖糖尿病（NOD）小鼠糖尿病累积发病率或传播的抑制作用或缺乏这种作用具有机制及治疗方面的意义。我们之前表明，以食物百分比形式持续给NOD小鼠投喂氨苯砜能以剂量依赖方式抑制糖尿病的累积发病率。在本实验中，雌性NOD同窝仔在糖尿病发病时被随机分组以接受氨苯砜（0.001%重量/重量，以食物百分比计）。最终接受氨苯砜的动物（n = 10）、仅接受小鼠饲料的动物（n = 9）或未患糖尿病的动物（n = 3）在10周龄时体重、血糖或糖化血红蛋白并无差异。接受或未接受氨苯砜的动物在糖尿病发病时的平均发病时间、平均血糖及平均糖化血红蛋白并无差异。接受氨苯砜的动物在糖尿病发病后第2、3和4周糖化血红蛋白显著更低（p≤0.03），且在糖尿病诊断后存活时间显著更长（7周对4周，p < 0.05）。总之，即使在高血糖开始后给药，氨苯砜也能调节NOD小鼠自身免疫性糖尿病的进展。
