Keller J B, Bevier W C, Jovanovic-Peterson L, Formby B, Durak E P, Peterson C M
California Polytechnic State University, San Luis Obispo 93407.
Diabetes Res Clin Pract. 1993 Oct-Nov;22(1):29-35. doi: 10.1016/0168-8227(93)90129-s.
The non-obese diabetic (NOD) mouse was used to investigate the effects of voluntary wheel running exercise on blood glucose levels, glycosylated hemoglobin, and longevity in Type 1 diabetes mellitus. In Experiment 1, diabetic and normoglycemic mice exercised 5 h/day, 5 days/week for 3 weeks matched with non-exercising controls. In diabetic animals a positive correlation was found between blood glucose and the number of revolutions performed (P < or = 0.02). Exercise also significantly lowered blood glucose between baseline and post-exercise in both diabetic and normoglycemic animals. In Experiment 2, mice exercised 2 h/day, 5 days/week. For the diabetic animals, glycosylated hemoglobin was lower than that of matched non-exercising diabetic animals at week 3 (11.1 +/- 0.6% vs. 15.0 +/- 1.6%, P < 0.001). Diabetic runners were able to train and significantly increased running in the first 4 weeks (P < 0.05). At the end of 9 weeks all 5 diabetic runners were alive, compared with 3 of 5 non-running diabetic animals. We conclude: (i) the NOD mouse is a useful model for the study of exercise in Type 1 diabetes, (ii) running exercise is associated with a drop in blood glucose, (iii) the amount of voluntary exercise performed correlates with blood glucose in diabetic animals, and (iv) diabetic mice will increase running distance in the first few weeks after diagnosis.
非肥胖型糖尿病（NOD）小鼠被用于研究自愿进行轮转跑步运动对1型糖尿病患者血糖水平、糖化血红蛋白和寿命的影响。在实验1中，糖尿病小鼠和血糖正常的小鼠每天运动5小时，每周运动5天，持续3周，与不运动的对照组进行匹配。在糖尿病动物中，发现血糖与跑步圈数之间存在正相关（P≤0.02）。运动还显著降低了糖尿病和血糖正常动物运动前后的血糖水平。在实验2中，小鼠每天运动2小时，每周运动5天。对于糖尿病动物，在第3周时糖化血红蛋白低于匹配的不运动糖尿病动物（11.1±0.6%对15.0±1.6%，P<0.001）。糖尿病跑步小鼠能够进行训练，并且在最初4周内跑步量显著增加（P<0.05）。在9周结束时，所有5只糖尿病跑步小鼠都存活，而5只不运动的糖尿病动物中有3只存活。我们得出结论：（i）NOD小鼠是研究1型糖尿病运动的有用模型；（ii）跑步运动与血糖下降有关；（iii）糖尿病动物的自愿运动量与血糖相关；（iv）糖尿病小鼠在诊断后的最初几周内会增加跑步距离。
