Shani J, Urbach L, Terkel J, Goldhaber G
Arch Int Pharmacodyn Ther. 1976 Jun;221(2):323-7.
Chronically-cannulated female rats that had been adapted to frequent handling were used for a kinetic study where oxytocin was injected into an indwelling atrial cannula and blood sampled every 5-10 min for 2 hr after the injection. The plasma was assayed for prolactin and LH by radioimmunoassay, in order to ascertain whether in cycling rats oxytocin exerts any effect on the circulating level of either hormone. The advantage of this experimental model is that each animal served as a control for itself, and that only minor stress was recorded during the experiments. The results suggest that oxytocin does not alter circulating LH levels, and complement previous reports on the lack of effect of oxytocin on serum prolactin in the cycling rat.
对已适应频繁处理的慢性插管雌性大鼠进行了一项动力学研究，将催产素注入留置的心房插管中，并在注射后2小时内每隔5 - 10分钟采集一次血液样本。通过放射免疫分析法测定血浆中的催乳素和促黄体生成素，以确定在处于发情周期的大鼠中，催产素是否对这两种激素的循环水平产生任何影响。该实验模型的优点是每只动物自身作为对照，并且在实验过程中记录到的应激较小。结果表明，催产素不会改变促黄体生成素的循环水平，这与先前关于催产素对处于发情周期大鼠血清催乳素无影响的报道相一致。
