Duan X, Jiang Y, Liu X
Second Affiliated Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1997;22(4):313-6.
Thirty eyes with 15 healthy white New Zealand rabbits subgrouped into two groups: right eye as an experimental group which was implanted Hunan aqueous drainage (HAD) and left eye served as self-control group in which a silicone band 7 mm in width and 7 to 10 mm in length was placed equatorially around the globe. Within 1 to 12 weeks postoperatively, we examined the anterior segment of the globe by the slit lamp microscopy (SLM) and made histopathological observation under light microscope after sacrifice and enucleation of eyeballs in five batches. SLM examination showed that 8 out of 15 eyes in experimental group showed mild or moderate ocular reaction which subsided within 2 to 14 days postoperatively. Histopathological observation revealed no obvious pathological lesions in the uveal tract tissues in the most globes. No foreign body macrophages were found. It indicates that HAD implant is nontoxic and nonallergenic, so it is adaptable for rabbit ocular tissue. The HAD implant can be used in human eyes, too.
30只眼睛来自15只健康的白色新西兰兔，被分为两组：右眼作为实验组，植入湖南房水引流物（HAD），左眼作为自身对照组，在眼球赤道部环绕放置一条宽7毫米、长7至10毫米的硅胶带。术后1至12周内，我们通过裂隙灯显微镜（SLM）检查眼球前段，并在术后分五批处死并摘除眼球后，在光学显微镜下进行组织病理学观察。SLM检查显示，实验组15只眼中有8只出现轻度或中度眼部反应，术后2至14天内消退。组织病理学观察发现，大多数眼球的葡萄膜组织中无明显病理病变。未发现异物巨噬细胞。这表明HAD植入物无毒且无致敏性，因此适用于兔眼组织。HAD植入物也可用于人眼。
