Li X, Zhao S, Wang Z
Department of Cardiovascular Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1997;22(4):320-2.
The plasma lipoprotein (a) [Lp(a)] levels were determined among 593 adults in Changsha city, Hunan province. The result showed that the distribution of Lp(a) levels in all the individuals was a skewness which can be normalized by data transformation into logarithm. Plasma Lp (a) concentration > 300 mg.L-1 was 34.8% in 209 subjects with coronary artery disease (CAD) and 17.3% in 305 health controls (P < 0.01). The Lp(a) levels were significantly higher in subjects with CAD than in health controls. Multiple regression stepwise analysis found that Lp(a) levels were positively correlated with CAD. This study indicates that plasma levels of Lp(a) are strongly related to CAD and may be an important independent risk factor for CAD.
在湖南省长沙市的593名成年人中测定了血浆脂蛋白(a)[Lp(a)]水平。结果显示，所有个体中Lp(a)水平的分布呈偏态分布，可通过数据转换为对数进行标准化。在209例冠心病（CAD）患者中，血浆Lp(a)浓度>300mg.L-1的占34.8%，在305例健康对照者中占17.3%（P<0.01）。CAD患者的Lp(a)水平显著高于健康对照者。多元逐步回归分析发现，Lp(a)水平与CAD呈正相关。本研究表明，血浆Lp(a)水平与CAD密切相关，可能是CAD的一个重要独立危险因素。
