Yagi T, Noda A, Itoh R, Yamada H, Nakashima N, Yokota M, Koike Y
Nagoya University College of Medical Technology.
Rinsho Byori. 1998 Nov;46(11):1168-72.
We investigated factors of daytime sleepiness in 22 middle-aged male patients with sleep apnea syndrome (SAS) using the Epworth sleepiness scale (ESS) and polysomnography. The subjects were classified into two groups according to ESS score as follows; low ESS group: ESS score < 10, and high ESS group; ESS score > or = 10. ESS score was significantly correlated with duration in which nocturnal oxygen saturation decreased below 90% (Time of SpO2 < 90%) (r = 0.54, p < 0.05). Time of SpO2 < 90% and percent of movement arousals at the termination of apnea/hypopnea (number of movement arousal/total number of apnea/hypopneas x 100) were significantly higher in high ESS group than in low ESS group. Our findings suggest that the severity of oxygen desaturation and sleep fragmentation caused by arousal response at the termination of apnea/hypopnea may be important factors of daytime sleepiness in patients with SAS.
我们使用爱泼沃斯思睡量表（ESS）和多导睡眠图，对22名患有睡眠呼吸暂停综合征（SAS）的中年男性患者日间嗜睡的相关因素进行了调查。根据ESS评分，将受试者分为两组：低ESS组，ESS评分<10；高ESS组，ESS评分≥10。ESS评分与夜间血氧饱和度降至90%以下的持续时间（SpO2<90%的时间）显著相关（r = 0.54，p<0.05）。高ESS组的SpO2<90%的时间以及呼吸暂停/低通气终止时的运动觉醒百分比（运动觉醒次数/呼吸暂停/低通气总数×100）显著高于低ESS组。我们的研究结果表明，呼吸暂停/低通气终止时的觉醒反应所导致的氧饱和度降低的严重程度和睡眠片段化，可能是SAS患者日间嗜睡的重要因素。
