Aoki S, Danjo K
Research Laboratory, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Yakugaku Zasshi. 1998 Nov;118(11):511-8. doi: 10.1248/yakushi1947.118.11_511.
Influence of tableting conditions on sticking was investigated using two formulations, the one formulation containing ibuprofen (formulation A) and the other being the standard formulation (formulation B). Sticking was observed on formulation A, and was not observed on formulation B. The degree of sticking was decreased with increase in compression pressure, and increased with compression speed. The shape of punch face was influenced the degree of sticking (sugar concave < bebel < flat). It was thought that sticking was observed when the adhesion between tablet and punch was larger than that among tableting granules. We investigated the pressure placed on a scraper (SCR), the adhesion between granules and metal, and boring hardness of tablet. The results showed that sticking was not observed when the SCR and/or the adhesion were small enough or boring hardness of tablet was high enough. Furthermore, it was suggested that boring hardness distribution would influence sticking.
使用两种制剂研究了压片条件对黏附的影响，一种制剂含有布洛芬（制剂A），另一种是标准制剂（制剂B）。在制剂A上观察到了黏附现象，而在制剂B上未观察到。黏附程度随压缩压力的增加而降低，随压缩速度的增加而增加。冲头表面形状影响黏附程度（糖凹面＜斜面＜平面）。据认为，当片剂与冲头之间的附着力大于压片颗粒之间的附着力时，就会观察到黏附现象。我们研究了刮刀上的压力（SCR）、颗粒与金属之间的附着力以及片剂的钻孔硬度。结果表明，当SCR和/或附着力足够小或片剂的钻孔硬度足够高时，未观察到黏附现象。此外，有人认为钻孔硬度分布会影响黏附。
