Forrest D M, Seminari E, Hogg R S, Yip B, Raboud J, Lawson L, Phillips P, Schechter M T, O'Shaughnessy M V, Montaner J S
British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Clin Infect Dis. 1998 Dec;27(6):1379-85. doi: 10.1086/515030.
The incidence and spectrum of primary AIDS-defining illnesses in human immunodeficiency virus-positive patients receiving antiretroviral drugs may have changed since the introduction of newer antiretroviral agents. We performed a retrospective analysis of patients enrolled in the British Columbia Drug Treatment Program who were ever prescribed antiretroviral drugs between 1 January 1994 and 31 December 1996. Rates were calculated on a 6-month basis. There were 344 AIDS cases diagnosed among 2,533 participants between 1994 and 1996. The incidence of primary AIDS diseases decreased from 1994 to 1996, with a sharp decline in 1995 and 1996. There was no statistically significant change in the incidence of primary AIDS diagnoses relative to one another, and Pneumocystis carinii pneumonia and Kaposi's sarcoma remain the most common AIDS index diagnoses. In patients receiving antiretroviral therapy in the modern era, the incidence of AIDS-defining illnesses has decreased substantially, but the spectrum of AIDS-defining illnesses remains unchanged.
自新型抗逆转录病毒药物问世以来，接受抗逆转录病毒药物治疗的人类免疫缺陷病毒阳性患者中，原发性艾滋病定义疾病的发病率和谱可能已发生变化。我们对1994年1月1日至1996年12月31日期间在不列颠哥伦比亚药物治疗项目中曾被开具抗逆转录病毒药物处方的患者进行了回顾性分析。发病率按6个月计算。1994年至1996年期间，2533名参与者中诊断出344例艾滋病病例。原发性艾滋病疾病的发病率从1994年到1996年有所下降，在1995年和1996年急剧下降。原发性艾滋病诊断的发病率相互之间没有统计学上的显著变化，卡氏肺孢子虫肺炎和卡波西肉瘤仍然是最常见的艾滋病指标诊断。在现代接受抗逆转录病毒治疗的患者中，艾滋病定义疾病的发病率已大幅下降，但艾滋病定义疾病的谱仍未改变。
