Krause B J, Schmidt D, Mottaghy F M, Halsband U, Tellmann L, Herzog H, Müller-Gärtner H W
Klinik für Nuklearmedizin, Universität Düsseldorf, Deutschland.
Nuklearmedizin. 1998;37(8):257-61.
In this study, neuroanatomical correlates of encoding and retrieval in paired associate learning were evaluated with positron emission tomography using auditorily presented highly imaginable words.
Six right-handed normal male volunteers took part in the study. Each subject underwent six O-15-butanol PET scans. On each of the six trials the memory task began with the injection of a bolus of O-15-butanol. The subjects had to learn and retrieve twelve word pairs (highly imaginable words, not semantically related). The presentation of nonsense words served as reference condition.
Recall accuracy after 2-4 presentations was high during the PET measurement. In both encoding and retrieval we found anterior cingulate activation. We show bilateral dorsolateral prefrontal activation during the encoding of auditorily presented word pair associates, whereas retrieval led to left frontal activation. Furthermore, we demonstrate the importance of the precuneus in the retrieval of highly imaginable word-pair associates.
Our results support the hypothesis of the presence of distributed widespread brain structures subserving episodic declarative memory.
在本研究中，使用正电子发射断层扫描技术，通过听觉呈现高度可想象的单词，评估配对联想学习中编码和检索的神经解剖学相关性。
六名右利手正常男性志愿者参与了该研究。每位受试者接受了六次O-15-丁醇PET扫描。在这六次试验中的每一次，记忆任务都从注射一剂O-15-丁醇开始。受试者必须学习和检索十二对单词（高度可想象的单词，语义上不相关）。无意义单词的呈现作为对照条件。
在PET测量期间，经过2至4次呈现后的回忆准确率很高。在编码和检索过程中，我们都发现前扣带回激活。我们发现，在听觉呈现单词对联想的编码过程中，双侧背外侧前额叶激活，而检索则导致左侧额叶激活。此外，我们证明了楔前叶在高度可想象单词对联想检索中的重要性。
我们的结果支持这样的假设，即存在分布广泛的脑结构，这些脑结构支持情景陈述性记忆。
