Miyashita N, Toyota E, Sawayama T, Matsumoto A, Mikami Y, Kawai N, Takada K, Niki Y, Matsushima T
Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama.
Intern Med. 1998 Nov;37(11):913-6. doi: 10.2169/internalmedicine.37.913.
The association of Chlamydia pneumoniae with atherosclerosis of coronary and carotid arteries and the aorta has been demonstrated by seroepidemiology and by detection of the organism in atheromata. We investigated the frequency of C. pneumoniae seropositivity in patients with acute myocardial infarction (AMI). C. pneumoniae-specific antibodies were measured by the microimmunofluorescence test in 160 AMI patients and 160 control subjects matched for age and gender. The odds ratios (ORs) were 2.2 (95% confidence interval (CI), 1.2 to 3.9) for immunoglobulin (Ig)G and 2.7 (95% CI, 1.7 to 4.3) for IgA. After adjustment for other cardiovascular risk factors of age, gender, hypertension, diabetes, cigarette smoking and serum cholesterol, the ORs were essentially unchanged. This study confirmed that the observations of an association between antibody against C. pneumoniae and coronary heart disease in Western nations is also present in Japan. Our results are comparable to the previous seroepidemiological studies reporting ORs of 2.0 or greater.
肺炎衣原体与冠状动脉、颈动脉及主动脉粥样硬化之间的关联已通过血清流行病学及在动脉粥样硬化斑块中检测该病原体得到证实。我们调查了急性心肌梗死（AMI）患者中肺炎衣原体血清阳性的频率。采用微量免疫荧光试验对160例AMI患者及160例年龄和性别相匹配的对照者检测了肺炎衣原体特异性抗体。免疫球蛋白（Ig）G的比值比（OR）为2.2（95%置信区间（CI），1.2至3.9），IgA的OR为2.7（95%CI，1.7至4.3）。在对年龄、性别、高血压、糖尿病、吸烟及血清胆固醇等其他心血管危险因素进行校正后，OR基本未变。本研究证实，西方国家中观察到的肺炎衣原体抗体与冠心病之间的关联在日本也存在。我们的结果与之前报道OR值在2.0或更高的血清流行病学研究结果相当。
