早期血浆置换治疗巴洛（Bickerstaff）脑炎的疗效

Efficacy of early plasmapheresis in Bickerstaff's encephalitis.

作者信息

Ozawa T, Onodera O, Inuzuka T, Soma Y, Tsuji S

机构信息

Department of Neurology, Brain Research Institute, Niigata University.

出版信息

Intern Med. 1998 Nov;37(11):986-9. doi: 10.2169/internalmedicine.37.986.

DOI:10.2169/internalmedicine.37.986

PMID:9868967

Abstract

Double filtration plasmapheresis (DFPP) was performed in a patient with Bickerstaff's brainstem encephalitis (BBE) in its early phase. He was a 27-year-old male patient suffering from diplopia, facial palsy and drowsiness following upper respiratory tract infection, and had high titers of immunoglobulin G (IgG) antibodies against ganglioside NeuAc(alpha)2-8NeuAc(alpha)2-3Gal(beta)1-3GalNAc(beta)1-4(NeuAc(al pha)2-8NeuAc(alpha)2-3)Gal(beta)1-4Glc(beta)1-1'Cer (GQ1b) in the serum. DFPP effected immediate improvement of his drowsiness, supporting the diagnosis of BBE. Our observations suggest that DFPP during the early phase of BBE efficiently prevents the progression of consciousness disturbances.

摘要

对一名处于早期的Bickerstaff脑干脑炎（BBE）患者进行了双重滤过血浆置换（DFPP）。他是一名27岁男性患者，在上呼吸道感染后出现复视、面瘫和嗜睡症状，血清中针对神经节苷脂NeuAc(α)2-8NeuAc(α)2-3Gal(β)1-3GalNAc(β)1-4(NeuAc(α)2-8NeuAc(α)2-3)Gal(β)1-4Glc(β)1-1'Cer（GQ1b）的免疫球蛋白G（IgG）抗体滴度很高。DFPP使他的嗜睡症状立即得到改善，支持了BBE的诊断。我们的观察结果表明，在BBE早期进行DFPP可有效防止意识障碍的进展。