Boulton A J
University of Manchester, UK.
Diabet Med. 1998;15 Suppl 4:S57-9. doi: 10.1002/(sici)1096-9136(1998120)15:4+<s57::aid-dia741>3.3.co;2-4.
Peripheral neuropathy is one of the most common long-term complications of Type 2 diabetes. A population-based study in the north of England showed that 42% of Type 2 diabetic patients had clinical evidence of neuropathy. The Diabetes Control and Complications Trial (DCCT) has shown that the incidence of neuropathy in Type 1 diabetes can be reduced by over 50% with intensive therapy and optimal glycaemic control. Hyperglycaemia is believed to be a major aetiological factor in the development of neuropathy in Type 2 diabetes. Neuropathy cannot be diagnosed through history alone; therefore, careful examination of the feet for evidence of sensory loss and an assessment of the circulation must form part of the annual review of each patient. Peripheral somatic and autonomic neuropathy, together with peripheral vascular disease, are major contributing factors to the development of foot ulcers. In addition, abnormalities of foot shape (e.g. claw toes, prominent metatarsal heads) and the presence of plantar callus are signs of foot-ulcer risk. Effective patient education can reduce the incidence of foot ulceration and amputation by over 50%; therefore, all patients with a high risk of foot ulcers should be informed and, if indicated, referred for regular podiatry. The team approach to diabetic foot problems is an effective method of providing treatment for active ulcers. This should be followed by appropriate education, the provision of follow up and if indicated, suitable footwear and hosiery. Key members of the team are the podiatrist, the specialist nurse and the orthotist; medical staff may include the diabetologist and a vascular or orthopaedic surgeon. Thus, the risk of foot ulceration and amputation can be reduced by careful screening and patient education, without the need for expensive equipment.
周围神经病变是2型糖尿病最常见的长期并发症之一。一项基于英国北部人群的研究表明,42%的2型糖尿病患者有神经病变的临床证据。糖尿病控制与并发症试验(DCCT)表明,强化治疗和最佳血糖控制可使1型糖尿病患者神经病变的发生率降低50%以上。高血糖被认为是2型糖尿病神经病变发生的主要病因。仅通过病史无法诊断神经病变;因此,对足部进行仔细检查以寻找感觉丧失的证据并评估循环系统,必须成为每位患者年度复查的一部分。周围躯体神经和自主神经病变,连同周围血管疾病,是足部溃疡发生的主要促成因素。此外,足部形状异常(如爪形趾、跖骨头突出)和足底胼胝的存在是足部溃疡风险的迹象。有效的患者教育可使足部溃疡和截肢的发生率降低50%以上;因此,所有足部溃疡高危患者均应被告知,并在必要时转诊接受定期足病治疗。采用团队方法处理糖尿病足部问题是治疗活动性溃疡的有效方法。随后应进行适当的教育、提供随访,并在必要时提供合适的鞋类和袜子。团队的关键成员是足病医生、专科护士和矫形师;医务人员可能包括糖尿病专科医生以及血管外科或矫形外科医生。因此,通过仔细筛查和患者教育,无需昂贵设备即可降低足部溃疡和截肢的风险。