Deng A Y
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614-5804, USA.
J Hypertens. 1998 Dec;16(12 Pt 1):1707-17. doi: 10.1097/00004872-199816120-00001.
Quantitative trait loci in Dahl rats Genetic and crude physical mapping have yielded chromosome regions containing quantitative trait loci for blood pressure in Dahl salt-sensitive rats. So far, the molecular identities of these loci are largely unknown. Intriguing still is how these quantitative trait loci would interact with each other to achieve an overall blood pressure effect Alleles of some loci previously identified as blood pressure quantitative trait loci in other rat strains appear to be the same between Dahl salt-sensitive and salt-resistant rats. Why do Dahl salt-resistant rats have low blood pressure whereas Dahl salt-sensitive rats develop high blood pressure? Recent findings With the use of congenic strains and 'double' congenics, these issues have begun to unravel. Certain quantitative trait loci exert major blood pressure effects (>20 mmHg) and each of them can be dissected as a monogenic trait Some appear to be located close to each other in the same chromosome region. Different quantitative trait loci interact epistatically to produce their combined blood pressure effects. 'Low' blood pressure alleles of one quantitative trait locus can compensate for the 'high' blood pressure alleles of other quantitative trait loci in the Dahl salt-resistant rat By integrating fine mapping and positional cloning strategies, blood pressure quantitative trait loci are being elucidated. Work in the rat may also facilitate genetic mapping of quantitative trait loci in humans.
达尔大鼠中的数量性状基因座 遗传和粗略物理图谱定位已经确定了达尔盐敏感大鼠中包含血压数量性状基因座的染色体区域。到目前为止，这些基因座的分子身份大多未知。同样有趣的是，这些数量性状基因座如何相互作用以实现总体血压效应。在其他大鼠品系中先前被确定为血压数量性状基因座的一些基因座的等位基因，在达尔盐敏感大鼠和盐抵抗大鼠之间似乎是相同的。为什么达尔盐抵抗大鼠血压低，而达尔盐敏感大鼠会出现高血压？ 最新发现 通过使用近交系和“双重”近交系，这些问题已开始得到解决。某些数量性状基因座对血压有主要影响（>20 mmHg），并且每个基因座都可以作为单基因性状进行剖析。有些似乎在同一染色体区域彼此靠近。不同的数量性状基因座上位相互作用以产生其联合血压效应。在达尔盐抵抗大鼠中，一个数量性状基因座的“低”血压等位基因可以补偿其他数量性状基因座的“高”血压等位基因。通过整合精细定位和位置克隆策略，正在阐明血压数量性状基因座。在大鼠中的研究也可能有助于人类数量性状基因座的遗传定位。
