Shigemori C, Wada H, Matsumoto K, Shiku H, Nakamura S, Suzuki H
Department of Surgery II, Mie University Medical School, Tsu, Japan.
Thromb Haemost. 1998 Dec;80(6):894-8.
Several studies have previously demonstrated tissue factor (TF) expression in solid tumors. In our study, we evaluated by immunohistochemical staining TF expression in 79 cases of colorectal cancer and 17 cases of metastatic cancer of the liver from colorectal cancer, and investigated the relationship between the clinicopathological features and TF expression. TF was detected in the tumor of 57% of colorectal cancer patients, and its expression was significantly increased (p=0.01) in metastatic tumors (88%). TF expression was more commonly observed in metastatic tumors than in any Dukes' stage of primary cancer. In primary cancer, the detection of TF was more frequent in cases with lymph node metastasis (Dukes' C, 63%) or with hematogenous metastasis (Dukes' D, 82%) than in tumors without lymph node or hematogenous metastasis (Dukes' A and B, 46%, p=0.03). These results suggest that the expression of TF is related with the metastatic potential of colorectal cancer.
此前已有多项研究证实实体瘤中存在组织因子（TF）表达。在我们的研究中，我们通过免疫组织化学染色评估了79例结直肠癌及17例结直肠癌肝转移癌中TF的表达情况，并研究了临床病理特征与TF表达之间的关系。在57%的结直肠癌患者肿瘤中检测到TF，其在转移瘤中的表达显著增加（p = 0.01）（88%）。与原发性癌的任何Dukes分期相比，TF表达在转移瘤中更常见。在原发性癌中，有淋巴结转移（Dukes C期，63%）或血行转移（Dukes D期，82%）的病例中TF检测频率高于无淋巴结或血行转移的肿瘤（Dukes A和B期，46%，p = 0.03）。这些结果表明TF的表达与结直肠癌的转移潜能相关。
