Richardson P, Bearman S I
Bone Marrow Transplant Program, University of Colorado Health Sciences Center, Denver 80262, USA.
Leuk Lymphoma. 1998 Oct;31(3-4):267-77. doi: 10.3109/10428199809059219.
Venocclusive disease of the liver (VOD) is one of the most common and serious complications following stem cell transplantation. High-dose chemotherapy or chemoradiotherapy injures the structures of Zone 3 of the liver acinus and produces the clinical syndrome of hepatomegaly or right upper quadrant pain, jaundice, and fluid retention. VOD occurs in up to 54% of stem cell transplant recipients and is fatal in 25-50% of them. While the clinical signs of VOD usually manifest during the first post-transplant week, late presentation can occur. The purpose of this review is to discuss the manifestations and pathophysiology of VOD and the options for prevention and treatment.
肝静脉闭塞病（VOD）是干细胞移植后最常见且严重的并发症之一。大剂量化疗或放化疗会损伤肝腺泡3区的结构，并引发肝肿大或右上腹疼痛、黄疸和液体潴留等临床综合征。高达54%的干细胞移植受者会发生VOD，其中25%-50%会因此死亡。虽然VOD的临床症状通常在移植后的第一周出现，但也可能出现延迟表现。本综述的目的是讨论VOD的表现、病理生理学以及预防和治疗方案。
