Kim Miriam, Rao Seema, Eickhoff Jens C, DeSantes Kenneth B, Capitini Christian M
Departments of Pediatrics.
Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, Houston, TX.
J Pediatr Hematol Oncol. 2020 Mar;42(2):145-148. doi: 10.1097/MPH.0000000000001422.
Hepatic sinusoidal obstruction syndrome (SOS) remains a serious complication of hematopoietic stem cell transplantation (HSCT). In this single institution retrospective case series, 18 children developed SOS after HSCT. Patients were treated with antithrombin III (ATIII), defibrotide, or ATIII followed by defibrotide. Twelve of 13 patients who were treated with ATIII therapy alone had complete resolution of SOS, including 4 of 5 children with severe SOS. In this limited cohort, ATIII was safe and successfully prevented progression of hepatic SOS following HSCT in the majority of children at our center.
肝窦阻塞综合征（SOS）仍然是造血干细胞移植（HSCT）的一种严重并发症。在这个单机构回顾性病例系列中，18名儿童在HSCT后发生了SOS。患者接受了抗凝血酶III（ATIII）、去纤苷或先使用ATIII再使用去纤苷的治疗。仅接受ATIII治疗的13名患者中有12名SOS完全缓解，其中5名重症SOS儿童中有4名缓解。在这个有限的队列中，ATIII是安全的，并且在我们中心的大多数儿童中成功预防了HSCT后肝SOS的进展。
