Begueret H, Labouyrie E, Dubus P, Sempe S, Goussot J F, Besse P, De Mascarel A, Merlio J P
Department of Pathology, Hôpital du Haut-Lévêque, Bordeaux, France.
Leuk Lymphoma. 1998 Oct;31(3-4):423-8. doi: 10.3109/10428199809059237.
We report a fatal primary cardiac non-Hodgkin's lymphoma in a 62 years old immunocompetent woman presenting with tamponade and complete atrioventricular block. CT-scan, echocardiography and autopsy examination showed a tumor largely infiltrating the heart without extracardiac involvement. A surgical biopsy revealed high grade B-cell non-Hodgkin's lymphoma with a misleading myelomonocytic CD68 (KPI) expression. Polymerase Chain Reaction analysis revealed a clonal rearrangement of the immunoglobulin heavy chain gene and confirmed the B-cell origin of the lymphoma. Our report also emphasizes the role of immunohistochemical and molecular techniques in the diagnosis.
我们报告了一例62岁免疫功能正常女性的致命性原发性心脏非霍奇金淋巴瘤，该患者表现为心包填塞和完全性房室传导阻滞。CT扫描、超声心动图和尸检显示肿瘤大量浸润心脏，无心脏外受累。手术活检显示为高级别B细胞非霍奇金淋巴瘤，伴有误导性的髓单核细胞CD68（KPI）表达。聚合酶链反应分析显示免疫球蛋白重链基因的克隆重排，证实了淋巴瘤的B细胞起源。我们的报告还强调了免疫组织化学和分子技术在诊断中的作用。
