Hjollund N H, Kold Jensen T, Bonde J P, Henriksen T B, Kolstad H A, Andersson A M, Ernst E, Giwercman A, Skakkebaek N E, Olsen J
Department of Occupational Medicine, Aarhus University Hospital, Denmark.
Scand J Work Environ Health. 1998 Oct;24(5):344-50. doi: 10.5271/sjweh.354.
The association between fertility and job strain defined as high job demands and low job control has not previously been studied. A follow-up study was conducted with prospective collection of information on job strain among women, achievement of pregnancy, and potential confounding variables.
A total of 297 Danish couples without previous reproductive experience was followed for a maximum of 6 menstrual cycles from termination of birth control until pregnancy. Job demand and job control were measured by a questionnaire developed by Karasek and his co-workers.
The odds ratio and 95% confidence interval (95% CI) for conception per menstrual cycle for women with high job strain was 0.9 (95% CI 0.5-1.5) when compared with that of women in low-strain jobs. Only in secondary analyses restricted to couples with no suspected competitive causes of reduced fertility was a statistically significant reduced odds found for women with high-strain jobs compared with all other jobs.
The main finding of this study did not corroborate a hypothesis of a substantial detrimental effect of job strain on fecundability.
生育能力与被定义为高工作要求和低工作控制的工作压力之间的关联此前尚未得到研究。我们进行了一项随访研究，前瞻性收集有关女性工作压力、怀孕情况及潜在混杂变量的信息。
对297对既往无生育经历的丹麦夫妇进行随访，从停止避孕到怀孕，最长随访6个月经周期。工作要求和工作控制通过Karasek及其同事编制的问卷进行测量。
与从事低压力工作的女性相比，工作压力高的女性每个月经周期受孕的优势比及95%置信区间（95%CI）为0.9（95%CI 0.5 - 1.5）。仅在针对无生育能力下降可疑竞争原因的夫妇的二次分析中，发现与所有其他工作相比，从事高压力工作的女性受孕优势比有统计学意义的降低。
本研究的主要发现并未证实工作压力对生育能力有实质性有害影响这一假设。
